Relief Therapeutics Shareholders Approve Business Combination with NeuroX

Relief Therapeutics Shareholders Approve Business Combination with NeuroX

• Shareholders approve all EGM proposals related to the combination with NeuroX
• Business combination expected to close in December 2025
• Relief to be renamed MindMaze Therapeutics Holding SA upon closing
• New board and executive committee members announced
• Companies to host joint press conference on November 25, 2025

GENEVA (Nov. 14, 2025) – RELIEF THERAPEUTICS Holding SA (SIX: RLF, OTCQB: RLFTF, RLFTY) (Relief or the Company), a biopharmaceutical company committed to delivering innovative treatment options for select specialty, unmet and rare diseases, announced that shareholders approved by a large majority all resolutions submitted to its extraordinary general meeting (EGM) held earlier today in Geneva, Switzerland. The approvals authorize the business combination between Relief and NeuroX Group SA (NeuroX) to create a publicly listed, digital neurotherapeutics company combining NeuroX's brain health platform with Relief's specialty biopharmaceutical portfolio.

Shareholders approved an ordinary capital increase through the issuance of 140 million new ordinary shares, to be paid in by contribution in kind of NeuroX shares, together with amendments to the capital band and conditional capital. The EGM also approved renaming the Company to MindMaze Therapeutics Holding SA upon completion of the business combination and elected Walid Hanna, Olaf Blanke, Michael Stuenkel, and Martin Reiss to the board of directors, joining Gregory Van Beek upon closing. The remaining incumbent directors will step down at that time. Other approved resolutions included the election of the nomination and compensation committee and minor amendments to the Company's articles of association.

The business combination is expected to close in December 2025, subject to remaining closing conditions, including the admission of the newly issued shares to trading on the SIX Swiss Exchange.

Upon completion of the business combination, Alexandre Capet is expected to serve as chief executive officer and Frédéric Condolo as chief technology officer of the combined company. Both are part of the current leadership of NeuroX and joined MindMaze in 2023. Mr. Capet has more than 25 years of experience in the life sciences sector, specializing in strategy, business development, and operations. Before joining MindMaze, he was global vice president of the Digital Business Unit at Bayer, and previously deputy CEO of Voluntis, a digital therapeutics company, following senior leadership roles at Sanofi. Mr. Condolo leads technology and artificial intelligence development and has more than 30 years of experience building and managing high-performing technical organizations. Before joining MindMaze, he was director of Valiantys Switzerland, an AI-powered digital transformation firm, and technical director at Ubisoft.

Press Conference – Relief and NeuroX will host a joint press conference on Tuesday, November 25, 2025, at 3:00 p.m. CET. An accompanying presentation with additional details on the combined company's strategic outlook will be published on Relief's website on the same day. The conference can be accessed via the following link:

https://mindmaze.zoom.us/j/81345965910
Passcode: 374338

Participants joining by phone may use Webinar ID 813 4596 5910 and can find international dial-in numbers at  https://mindmaze.zoom.us/u/kcYGXs92CP

ABOUT RELIEF
Relief is a commercial-stage biopharmaceutical company dedicated to advancing treatment paradigms and improving the lives of patients with rare and debilitating diseases. With core expertise in drug delivery systems and drug repurposing, Relief's clinical pipeline includes innovative treatments designed to address critical unmet medical needs in rare dermatological, metabolic and respiratory conditions. The Company has also successfully brought several approved products to market through licensing and distribution partnerships. Headquartered in Geneva, Relief is listed on the SIX Swiss Exchange under the symbol RLF and quoted in the U.S. on OTCQB under the symbols RLFTF and RLFTY. For more information, visit www.relieftherapeutics.com.

ABOUT NEUROX
NeuroX is a Swiss-based, commercial-stage company that in 2025 acquired strategic assets of MindMaze Group SA and MindMaze SA (MindMaze), including intellectual property and the MindMaze^® brand. MindMaze pioneered first-of-its-kind digital neurotherapeutics that provide disease-modifying motor and cognitive treatments for neurological diseases and brain disorders. Built on an advanced brain technology platform integrating software, sensors, and telehealth, NeuroX solutions are deployed globally across clinics and home settings. The company's clinically validated technology has demonstrated significant medico-economic outcomes across conditions such as stroke, Parkinson's disease, and at-risk aging. NeuroX continues to expand its R&D pipeline into adjacent neurological indications, including multiple sclerosis, spinal cord injury, traumatic brain injury, and Alzheimer's disease.

CONTACT
RELIEF THERAPEUTICS Holding SA
Jeremy Meinen
Chief Financial Officer
contact@relieftherapeutics.com

DISCLAIMER
This press release contains forward-looking statements, which may be identified by words such as "believe," "assume," "expect," "intend," "may," "could," "will," or similar expressions. These statements are based on current plans and assumptions and are subject to risks and uncertainties that could cause actual results, financial condition, performance, or achievements to differ materially from those expressed or implied. Such factors include, but are not limited to, changes in economic conditions, market developments, regulatory changes, competitive dynamics, and other risks or changes in circumstances. There can be no assurance that the proposed business combination will be completed within the anticipated timeframe or at all. This communication is provided as of the date hereof, and Relief undertakes no obligation to update any forward-looking statements contained herein as a result of new information, future events or otherwise.