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29.10.2025 15:29:50
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Press Release: Novartis ianalumab first drug to -2-
Reimagine medicine with us: Visit us at https://www.novartis.com/ https://www.novartis.com and connect with us on https://www.linkedin.com/company/novartis/ LinkedIn, https://www.facebook.com/novartis/ Facebook, https://twitter.com/Novartis X/Twitter and https://instagram.com/novartis?igshid=MzRlODBiNWFlZA==__;!!N3hqHg43uw!pjp8z253J5NjaOYrW65UbAAlHeHRdQ-w0m4ezZxEQEl0ptafXN2M99VRIk39pf49PAc8NbK93Pxp3uaSBQkAf8oEnzWXG8Sk$ Instagram.
References
1. Thomas GB, Xavier M, Stephanie F et al. Ianalumab demonstrates
significant reduction in disease activity in patients with Sjögren's
Disease: Efficacy and safety results from two global Phase 3, randomized,
placebo-controlled double-blind studies (NEPTUNUS-1 and NEPTUNUS-2).
Presented at the American College of Rheumatology (ACR) Congress; October
24-29, 2025; Chicago, Illinois
2. National Academies of Sciences, Engineering, and Medicine; Health and
Medicine Division; Board on Health Care Services; Committee on Selected
Immune Disorders and Disability. Sjögren's Disease/Syndrome. [Last
accessed: October 2025] https://www.ncbi.nlm.nih.gov/books/NBK584486/
3. Dorner T et al, Safety and Efficacy of ianalumab in patients with
Sjögren's disease: 52-week results from a randomized,
placebo-controlled, Phase 2b dose-ranging study, Arthritis and
Rheumatology 2025, 77(5):560-570
4. Lee AY, Qi Z, Jackson KJ, et al. Self-reactive B cells are increased in
all major stages of peripheral development in Sjögren's disease.
Immunology & Cell Biology 2025; 103: 401-410.
5. Both T, Dalm VA, van Hagen PM, et al. Reviewing primary Sjögren's
syndrome: beyond the dryness - From pathophysiology to diagnosis and
treatment. Int J Med Sci 2017; 14: 191-200.
6. Cornec D, Devauchelle-Pensec V, Tobón GJ, et al. B cells in
Sjögren's syndrome: from pathophysiology to diagnosis and treatment.
J Autoimmun 2012; 39: 161-167.
7. ClinicalTrials.gov NCT05350072
https://clinicaltrials.gov/study/NCT05350072 [Last accessed: October
2025]
8. ClinicalTrials.gov NCT0539214
https://clinicaltrials.gov/study/NCT05349214 [Last accessed: October
2025]
9. ClinicalTrials.gov NCT05985915
https://clinicaltrials.gov/study/NCT05985915 [Last accessed: October
2025]
10. ClinicalTrials.gov NCT05653219
https://clinicaltrials.gov/study/NCT05653219?intr=ianalumab&aggFilters=phase:3&rank=9
[Last accessed: October 2025]
11. ClinicalTrials.gov NCT05639114
https://www.clinicaltrials.gov/study/NCT05639114 [Last accessed: October
2025]
12. ClinicalTrials.gov NCT05126277
https://clinicaltrials.gov/study/NCT05126277 [Last accessed: October
2025]
13. ClinicalTrials.gov NCT05648968
https://clinicaltrials.gov/study/NCT05648968 [Last accessed: October
2025]
14. ClinicalTrials.gov NTC06470048
https://clinicaltrials.gov/study/NCT06470048 [Last accessed: October
2025]
15. Novartis to strengthen oncology pipeline with agreement to acquire
MorphoSys [AG Press release]. [Press release]. Available at: Novartis to
strengthen oncology pipeline with agreement to acquire MorphoSys AG for
EUR 68 per share or an aggregate of EUR 2.7bn in cash | Novartis
https://www.novartis.com/news/media-releases/novartis-strengthen-oncology-pipeline-agreement-acquire-morphosys-ag-eur-68-share-or-aggregate-eur-27bn-cash
[Last accessed: October 2025]
16. Negrini S et al, Sjögren's syndrome: a systemic autoimmune disease,
Clin Exp Med. 2022; 22(1): 9--25
17. Maleki Fischbach-M, et al, Manifestations and management of
Sjögren's disease, Arthritis Res Ther, 2024; 26(1):43
18. Mariette, Primary Sjögren's symptoms, New England Journal of
Medicine, 2018, 378;10
19. Kerry Gairy et al, Burden of illness among subgroups of px with primary
SjD and systemic involvement, Rheumatology 2021, Volume 60, Issue 4,
April 2021, Pages 1871--1881
20. Conrad N, et al, Incidence, prevalence, and co-occurrence of autoimmune
disorders over time and by age, sex, and socioeconomic status: a
population-based cohort study of 22 millions individuals in the UK,
Lancet. 2023;401(10391):1878-1890;
21. Narváez J et al, Prevalence of Sjögren's syndrome in the
general adult population in Spain: estimating the proportion of
undiagnosed cases, Sci Rep. 2020;10(1):10627
# # #
Novartis Media Relations
E-mail: media.relations@novartis.com
Novartis Investor Relations
Central investor relations line: +41 61 324 7944
E-mail: investor.relations@novartis.com
(END) Dow Jones Newswires
October 29, 2025 10:30 ET (14:30 GMT)
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Analysen zu Novartis AG
| 21.11.25 | Novartis Neutral | UBS AG | |
| 21.11.25 | Novartis Buy | Deutsche Bank AG | |
| 21.11.25 | Novartis Underweight | Barclays Capital | |
| 21.11.25 | Novartis Outperform | Bernstein Research | |
| 20.11.25 | Novartis Neutral | UBS AG |
Krypto-Crash oder Einstiegs-Chance? – Bernhard Wenger von 21Shares zu Gast im BX Morningcall
Im BX Morningcall spricht Krypto-Experte Bernhard Wenger von @21shares über seinen Weg vom klassischen ETF-Geschäft in die Welt der Krypto-ETPs und erklärt, warum Bitcoin & Co. längst nicht ausgereizt sind. Er beleuchtet den Wandel von einem vorwiegend retailgetriebenen Markt hin zu immer mehr institutionellen Investoren, die über regulierte, physisch besicherte Produkte wie Bitcoin- und Krypto-ETPs investieren. Themen sind unter anderem Volatilität und „Krypto-Winter“, strenge Compliance- und Geldwäschereiregeln, Kostenstrukturen, Unterschiede im DACH-Raum sowie die Rolle des neuen US-Bitcoin-ETFs und des strategischen Investors FalconX für die nächste Wachstumsphase von 21Shares.
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Fokus auf Notenbanken: SMI kaum bewegt erwartet -- DAX dürfte freundlich starten -- Asiatische Börsen uneins - Verluste in JapanAm heimischen Aktienmarkt ist am Freitag vorbörslich kaum Bewegung zu sehen, während der deutsche Leitindex auf einen höheren Start zusteuert. Die asiatischen Aktienmärkte entwickeln sich zum Wochenausklang unterschiedlich. Die US-Börsen tendierten am Donnerstag letztlich in unterschiedliche Richtungen.


