Press Release: PSMAddition data show Novartis -2-

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Novartis is an innovative medicines company. Every day, we work to reimagine medicine to improve and extend people's lives so that patients, healthcare professionals and societies are empowered in the face of serious disease. Our medicines reach nearly 300 million people worldwide.

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Disclosure: Dr. Tagawa is a paid consultant for Novartis.

References

1. Novartis. Data on file.

2. Hussain M, Fizazi K, Shore ND, et al. Metastatic hormone-sensitive

prostate cancer and combination treatment outcomes. JAMA

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cancer: advances in treatment and symptom management. Curr Treat Options

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4. Morris M, Castellano D, Herrmann K, et al. 177Lu-PSMA-617 versus a change

of androgen receptor pathway inhibitor therapy for taxane-naive patients

with progressive metastatic castration-resistant prostate cancer

(PSMAfore): a phase 3, randomised, controlled trial. Lancet. 2024.

doi:10.1016/S0140-6736(24)01653-2.

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Castration-Resistant Prostate Cancer. N Engl J Med.

2021;385(12):1091-1103. doi:10.1056/NEJMoa2107322.

6. Pluvicto [prescribing information]. East Hanover, NJ: Novartis

Pharmaceuticals Corporation; 2025.

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until metastatic castration-resistant prostate cancer: an epidemiological

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oncological outcomes of metastatic hormone-sensitive prostate cancer and

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patients. Eur Urol Open Sci. 2024;66:46-54.

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metastatic castration-resistant prostate cancer: qualitative findings

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management in patients with biochemically recurrent prostate cancer. J

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for bone metastasis detection in prostate cancer patients: potential

impact on bone scan guidelines. J Nucl Med. 2020;61(3):405-11.

15. Minner S, Wittmer C, Graefen M, et al. High level PSMA expression is

associated with early PSA recurrence in surgically treated prostate

cancer. Prostate. 2011;71(3):281-8.

16. Clinicaltrials.gov. NCT04720157. An International Prospective Open-label,

Randomized, Phase III Study Comparing 177Lu-PSMA-617 in Combination With

SoC, Versus SoC Alone, in Adult Male Patients With mHSPC (PSMAddition).

Accessed October 2025. https://clinicaltrials.gov/study/NCT04720157.

17. University of Chicago Medicine. Lutetium-177 PSMA Therapy for Prostate

Cancer (Pluvicto). Accessed October 2025.

https://www.uchicagomedicine.org/cancer/types-treatments/prostate-cancer/treatment/lutetium-177-psma-therapy-for-prostate-cancer.

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Tepper JE, Foote RE, Michalski JM, eds. Gunderson & Tepper's Clinical

Radiation Oncology. 5th ed. Elsevier, Inc. 2021;71(3):209-249.

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(END) Dow Jones Newswires

October 19, 2025 10:30 ET (14:30 GMT)